Omeprazole (Multiple-Unit Pellet System) is indixated in- Duodenal and Gastric ulcers NSAID-induced gastric and duodenal ulcers Reflux Oesophagitis GERD (Gastroesophageal Reflux Disease) Eradication of H. pylori with appropriate antibiotics Zollinger-Ellison Syndrome

Each film coated MUPS tablet contains 20 mg Omeprazole enteric coated micro pellets

Proton Pump Inhibitor

Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.Clinical advantage of omeprazole mups tablet compared to conventional modified-release omeprazole tablets and pellet-filled omeprazole capsules: Ensures greater bioavailability Ensures uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax (peak time and peak plasma concentration) Ensures lesser possibility of dose dumping Is a combination of fast acting and sustained action Ensures uniform drug release Once daily dosing Ensures lesser chance of localized irritation Ensures better and more uniform drug absorption Better than capsules in reducing the esophageal residence time Minimizes fluctuation in plasma concentration of drug

Adult: GERD (Gastroesophageal Reflux Disease): 20 mg Once daily for 4 weeks Gastric ulcer: 20 mg Once daily for 4-8 weeks; in severe cases Twice daily Duodenal ulcer: 20 mg Once daily for 2-4 weeks; in severe cases Twice daily NSAID-induced ulceration: 20 mg Once daily for 4-8 weeks Reflux esophagitis: 20 mg Once daily for 4-8 weeks; in severe cases Twice daily H. pylori eradication (Omeprazole MUPS tablet with Amoxicillin and Clarithromycin or Metronidazole): 20 mg Twice daily for 1 week Zollinger-Ellison Syndrome: 60 mg Once daily; Usual maintenance, 20-120mg daily Children: Acid regurgitation in GERD (Gastroesophageal Reflux Disease): 20 mg Once daily for 2-4 week Reflux esophagitis: 20 mg Once daily for 4-8 weeks

Swallow the tablet whole with a glass of water. The tablet must not be chewed or crushed. ORIf the patients have trouble swallowing the tablets, put the tablet into a glass of water (Do not use other liquids). Stir the preparation until the tablets disintegrate. Then drink the liquid within 30 minutes. Stir the mixture just always before drinking.

Omeprazole is metabolized through CYP2C19 . When starting or stopping treatment with Omeprazole should be taken into account potential interactions with medicines which are CYP2C19 metabolized.

Omeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.

Not known to be harmful. Omeprazole can be used during pregnancy. Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used.

Omeprazole tablet should be used carefully if the patient has severe liver dysfunction and severe renal impairment.

Store in a cool (below 30° C) and dry place, protected from light and moisture.